SSRIs selective serotonin reuptake inhibitors such as Prozac, Paxil and Zoloft revolutionized the treatment of depression and related disorders when they arrived on the market in the s. But research has found that SSRIs can cause serious side effects ranging from withdrawal complications to birth defects to suicidal thoughts and behavior in younger patients.
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Eleven percent of Americans aged 12 years and over take an antidepressant medication, according to the Centers for Disease Control and Prevention. The use of antidepressants increased nearly percent between and SSRIs are the most common class of antidepressants in the U.
SSRIs are prescribed to treat depression, anxiety disorders, panic attacks and personality disorders. They have been shown to be more effective in severe cases of depression than in mild cases. Before taking any prescription medication as directed by your doctor, it is important to ask common uses and administration of paxil prescribing doctor questions about the treatment and its pros and cons.
Below are some of the frequently asked questions about SSRIs. Doctors are more likely to prescribe SSRIs to women. One in four women in their 40s and 50s take antidepressants, and 13 percent of pregnant women take these drugs. There are several reasons why doctors prescribe SSRIs. Some are for uses not approved by the U.
Food and Drug Administration, known as off-label uses. Nerve cells in our brain use various chemicals to pass on impulses. SSRIs work by increasing the levels of a brain chemical called serotonin, which plays a key role in mood. The body naturally produces serotonin and keeps it at a active pravastatin level, but SSRIs can increase that level by blocking inhibiting the re-absorption reuptake of serotonin.
These feelings should ease or subside on their own. This is especially true if patients have a history of depression. Prozac fluoxetine is the only FDA-approved medication for treating depression in children 8 and older, while Lexapro escitalopram is approved for children 12 to Prozac, Zoloft sertraline and Luvox fluvoxamine maleate are approved for use in children and adolescents for the treatment of obsessive-compulsive disorder.
SSRIs are usually taken daily. The goal is to ease or eliminate the symptoms within the first few weeks to months. Treatment duration depends on several factors, including the severity of the symptoms and how well each individual responds to treatments. Most patients take SSRIs for several months, but some may require years of treatment.
According to the CDC, 14 percent of Americans taking antidepressants have done so for 10 years or longer. The duration also depends on the chance of relapse.
Patients with a history of depression or those going through a traumatic life police action plans may experience a relapse of major depression.
Our bodies respond to medications in different ways. Doctors may end up prescribing a number of different SSRIs and dosage options common uses and administration of paxil a patient finds one that works. In general, the effectiveness is usually tied to the severity of the depression or anxiety disorder. According to a study from the Institute for Quality and Efficiency in Health Care, about 40 to 60 out of people who took an antidepressant noticed an improvement in their symptoms within six to eight weeks.
Typically, someone with an anxiety disorder such as obsessive-compulsive disorder OCD or generalized anxiety disorder GAD may see improvements faster compared to patients with severe depression. Each has slightly different pharmacological and pharmacokinetic characteristics, along with varying molecular structures. In other words, each drug has its own active ingredient with the same goal in mind.
SSRIs have a number of common side effects, including fatigue, weight loss, apathy, insomnia, headaches, nausea and pupil dilation. They are also linked to sexual side effects such as repressed libido, erectile dysfunction impotence for men and difficulty achieving orgasm for men and women, common uses and administration of paxil.
Side effects are more common with higher doses and are likely to improve or go away completely once the body adjusts to the medication, common uses and administration of paxil. However, SSRI use can also lead to serious side effects, some of which are life-threatening. A lower concentration of serotonin in platelets increases the acetaminophen and narcolepsy for stomach or uterine bleeding, which means an increased need for a blood transfusion during or after surgery.
Elderly people especially should be monitored for this condition from the beginning of treatment. Another serious concern for SSRI patients is whether they will suffer withdrawal symptoms when they stop taking the antidepressants.
SSRIs technically are not considered addictive because they do not cause cravings in the body when the patient stops taking the drugs. However, studies show that the antidepressants can make users dependent on the drugs, and patients can suffer withdrawal symptoms. Drug dependency is the state where a person needs steady or increasing doses of the drug to maintain normal functioning. Patients are warned not to stop taking SSRIs suddenly because they common uses and administration of paxil experience withdrawal side effects.
In severe cases, patients will have a collection of symptoms called SSRI Discontinuation syndrome, which can last up to several weeks. However, all SSRIs can be prescribed to children and teens as an off-label treatment for depression and anxiety disorders. Unfortunately, this may have resulted in common uses and administration of paxil suicide attempts among youth who needed antidepressants but did not take them because of the warning. A study found that antidepressant use in adolescents dropped 31 percent after the FDA issued the black box warning, common uses and administration of paxil, but suicide attempts among youth increased 22 percent.
Parents and caregivers of children being treated for depression with SSRIs should watch for worsening irritability, nervousness, agitation, mood instability or sleeplessness. Suicidal thoughts and behaviors are the most common symptoms of major depression for all ages.
Doctors and their patients should carefully weigh the risks with the benefits when prescribing SSRIs to treat depression. One way the agency has conveyed this warning is with letter grades, or categories, that are assigned to prescription medications to denote their safety ratings. Most SSRIs are Category C, meaning they have been known to harm laboratory animals when they ingested the drugs in large quantities. Paxil is the one exception. Zoloft and Prozac are the two most common SSRIs prescribed to pregnant women, but Paxil or any other SSRI can be prescribed if doctors think the benefits of the medication outweigh the potential common uses and administration of paxil. Untreated depression in pregnant women can also lead to serious complications, including continued depression after delivery postpartum depression and even the potential of pregnancy termination or suicide.
A comprehensive study from the National Center on Common uses and administration of paxil Defects and Developmental Disabilities revealed that the most common reported links include heart, brain and abdominal birth defects, common uses and administration of paxil. Drug manufacturers have paid billions in government fines, class-action settlements and lawsuit verdicts over potential dangers of SSRI medications.
Some notable ones include:. SSRIs are considered second-generation antidepressants and are often prescribed to treat depression before other types of antidepressants, including serotonin and noradrenaline reuptake inhibitors SNRIs and tricyclic antidepressants TCAs.
SSRIs can improve the symptoms of depression, but they can also cause serious side effects. A study from researchers at the Nordic Cochrane Centre and the University of Copenhagen found that patients who were given antidepressants but were not truly clinically depressed had a higher risk of suicidal thoughts or behaviors while using the medications. SSRIs should only be taken if the patient and their doctor or mental health professional believe it is the best possible option for treating severe depression or a serious anxiety disorder.
Serotonin and noradrenaline reuptake inhibitors SNRIs work similarly to SSRIs, but instead of increasing only serotonin levels, SNRIs also increase the amount of noradrenaline, a hormone that produces a wide range of effects on the body. However, common uses and administration of paxil, SNRIs may decrease libido, cause weight gain and increase actonel effectiveness for elderly women and drowsiness.
More common uses and administration of paxil side effects include birth defects in pregnant women and a risk of withdrawal from discontinuation. Tricyclic antidepressants TCAs are an older class of antidepressants, having physical activity cardiovascular disease available for more than 50 years.
They can be as effective as newer antidepressants, but they usually carry more side effects, including dizziness, constipation and dry mouth. TCAs might be prescribed if other antidepressants are proven ineffective. The most common alternative is therapy, which helps a person cope with feelings of hopelessness or anxiety. Cognitive behavioral therapy fema approved mitigation action plans a type of psychotherapy in which negative patterns of thought are challenged in order to change unwanted behavior patterns.
A study published in The Lancet discovered that nearly half of patients who had depression and were resistant to antidepressant medications benefited from cognitive behavioral therapy.
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Matt Mauney is a writer and researcher for Drugwatch. He is an award-winning journalist with a decade of professional experience. He also has a double minor in public relations and broadcasting.
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Did You Know Females are 2. Recommended Dosage 10 mg to 90 mg. Recommended Dosage 25 mg to mg. Recommended Dosage 20 mg to 50 mg.
Recommended Dosage 20 mg to 40 mg, common uses and administration of paxil. Recommended Dosage 10 mg to 20 mg. Common uses and administration of paxil is not FDA approved to treat depression but is prescribed as an off-label use. Some Withdrawal Side Effects Include:.
Discontinuation Syndrome In severe cases, patients will have a collection of symptoms called SSRI Discontinuation syndrome, which can last up to several weeks. Common Symptoms of Discontinuation Syndrome Include:. Clinical Fact Clinical studies found no significant correlation to an increased risk of suicidality in adults 25 and older and a reduced risk in adults 65 and older.
Antidepressants increase the risk of suicidal thinking and behavior suicidality in children and adolescents with major depressive disorder MDD and other psychiatric disorders. Anyone considering the use of [Drug Name] or any other antidepressant in a child or adolescent must balance this risk with the clinical need.