Chronic alcohol abusers may be at increased risk of hepatotoxicity during treatment with acetaminophen APAP. Severe liver injury, including cases of acute liver failure resulting in liver transplant and death, has been reported in patients using acetaminophen. Therapy with acetaminophen should be administered cautiously, if at all, in patients who consume three or more alcoholic drinks a day.
In general, patients should avoid drinking alcohol what is acetaminophen tablets taking acetaminophen-containing medications. They should acetaminophen contraindications for glaucoma be advised to seek medical attention if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, acetaminophen contraindications for glaucoma, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.
Acetaminophen is primarily metabolized in the liver to inactive forms. However, small quantities are converted by minor pathways to metabolites that can cause hepatotoxicity or methemoglobinemia.
Patients with hepatic impairment may be at increased risk of toxicity due to increased minor metabolic pathway activity. Likewise, chronic or overuse of acetaminophen can saturate the primary hepatic enzymes and lead to increased metabolism by minor pathways. Therapy with acetaminophen should be administered cautiously in patients with hepatic insufficiency. Clinical monitoring of hepatic function is recommended.
Instruct patients to avoid drinking alcohol while taking acetaminophen-containing medications. In cardiac tissues, these agents may produce positive chronotropic and inotropic effects via stimulation of beta- 1 adrenergic receptors. Cardiac output, oxygen consumption, and acetaminophen contraindications for glaucoma work of the heart may be increased.
In the peripheral vasculature, vasoconstriction may occur via stimulation of acetaminophen contraindications for glaucoma adrenergic receptors. Palpitations, tachycardia, arrhythmia, hypertension, reflex bradycardia, coronary occlusion, cerebral vasculitis, myocardial infarction, cardiac arrest, and death have been reported. Some of these agents, particularly ephedra alkaloids ephedrine, ma huang, phenylpropanolaminemay also predispose patients to hemorrhagic and ischemic stroke.
Therapy with sympathomimetic agents should generally be avoided or administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, or underlying cardiovascular or cerebrovascular disorders.
Several oral acetaminophen and acetaminophen-combination products, particularly flavored chewable tablets, contain the artificial sweetener, aspartame NutraSweet. Aspartame is converted to phenylalanine in the gastrointestinal tract following ingestion.
Chewable and effervescent formulations of acetaminophen products may also contain phenylalanine. Caution should be used when prescribing antitussives such as dextromethorphan and benzonatate in patients with psychiatric or emotional conditions.
Isolated instances of bizarre behavior, including mental confusion and visual hallucinations have been reported in patients taking antitussives, specially when combined with other prescribed drugs such as monoamine oxidase inhibitors. Sympathomimetic agents may cause or worsen urinary difficulty in patients with prostate enlargement due to smooth muscle contraction in the bladder neck via stimulation of alpha-1 adrenergic receptors, acetaminophen contraindications for glaucoma.
Therapy with sympathomimetic agents should be administered cautiously in patients with hypertrophy or neoplasm of the prostate. Sympathomimetic agents may cause increases in blood glucose concentrations. These effects are usually transient and slight but may be significant with dosages higher than those normally recommended. Therapy with sympathomimetic agents should be administered cautiously in patients with diabetes mellitus. Closer monitoring of blood glucose concentrations may be appropriate.
Sympathomimetic agents can induce transient mydriasis via stimulation of alpha-1 adrenergic receptors. In patients with anatomically narrow angles or narrow-angle glaucoma, pupillary dilation can provoke an acute attack. In patients with other forms of glaucoma, mydriasis may occasionally increase intraocular pressure. Therapy with sympathomimetic agents should be administered cautiously in patients with or predisposed to glaucoma, particularly narrow-angle glaucoma.
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We comply with acetaminophen contraindications for glaucoma HONcode standard for trustworthy health information - verify here. References Gillette JR "An integrated approach to the study of chemically reactive metabolites of acetaminophen.
Arnman R, Olsson R "Elimination of paracetamol in chronic liver disease. American Pharmaceutical Association How safe is it? American Medical Association; Role of diet pills and cold remedies.
Benign Prostatic Hyperplasia, Prostate Tumor. Drug Interaction Classification The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit, acetaminophen contraindications for glaucoma. Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Unknown No information available. Availability Over the counter. Subscribe to free Drugs. FDA alerts for all medications.